Safety and Effectiveness of Concomitant Mitral Transcatheter Edge-to-Edge Repair and Left Atrial Appendage Closure

Background: Concomitant mitral transcatheter edge-to-edge repair (M-TEER) and left atrial appendage closure (LAAC) showed to be a feasible approach optimize the treatment of patients eligible for both procedures, but mid-term outcomes are unclear. Methods: We retrospectively analyzed consecutive undergoing M-TEER enrolled in local prospective Getting Reduction Mitral Insufficiency by Percutaneous Clip Implantation (GRASP) registry. compared isolated (n = 58, 58.5%) with those concomitant LAAC 41, 41.5%) from January 2018 December 2022. The primary endpoint was composite all-cause death, stroke or systemic embolism, hospitalization heart failure, bleeding at 1 year. co-primary procedural success. Results: similar between M-TEER+LAAC (Kaplan Meier (KM) estimates 36.6% vs. 44.8%; plog-rank 0.75). Procedural success also (92.7% 94.8%; p 0.69). At 1- year, minor bleeds were lower (KM 0.0% 18.9%; < 0.01). Conclusion: In MR AF treatment, combined as safe an M-TEER-alone strategy associated